All Title Author
Keywords Abstract


Evaluation of whole body hypothermia on term neonates with hypoxic ischemic encepholopathy

Keywords: Hypothermia , hypoxic ischemic encephalopathy , newborn , perinatal asphyxia

Full-Text   Cite this paper   Add to My Lib

Abstract:

Aim: To investigate the effect of whole body hypothermia on short term neonatal morbidities and long term neurodevelopmental outcome in term neonates with hypoxic ischemic encephalopathy. Material and Method: Neonates with perinatal asphyxia and hypoxic ischemic encepholopathy (stage 2 and 3) were enrolled. Patients were divided into 2 groups according to findings observed on amplitude-integrated electroencephalography (aEEG). Patients with abnormal aEEG pattern in the first six hours after birth were defined as group 1 and others as group 2. Patients in group 1 were treated with whole body hypothermia. Neurodevelopmental outcome was evaluated at 18 months of age in survivors using Bayley Scales of Infant Development II. Mental developmental index and psychomotor development index scores were calculated.Results: Thirty five patients were enrolled (M/F=17/18), 18 (51%) of whom were treated with hypothermia. Bradycardia was observed in 44.4% of patients in group 1 and 5.9% of patients in group 2 (p=0.04). Incidence of other possible adverse events related to hypothermia were similar between the two groups. Mortality was higher in group 1 (p=0.03). In group 1, 70% of the patients and in group 2, 86% of the patients were evaluated using Bayley Scales of Infant Development II. Although patients treated with hypothermia had a higher mental developmental index and psychomotor development index scores, the difference was not statistically significant.Conclusions: Whole body hypothermia can be safely applied in term neonates with HIE. Hypothermia may improve neurodevelopmental outcome. (Turk Arch Ped 2011; 46: 286-91)

Full-Text

comments powered by Disqus