Background and Design: The aim of this study was to determine the efficiency of 1064 nm Nd: YAG laser in different types of verruca.Material and Method: A prospective descriptive study was planned. The study group constituted of 198 patients who had referred to the dermatology outpatient clinic between September 2007 and September 2008 with warts located at different sites and not previously treated.Results: Of the 198 patients aged 7-65 years who applied to our outpatient clinic during the study, 83 (41.9%) were female, 115 (58.1%) were male and the female/male ratio was 0.72; the total wart number, the mean wart number, and standard deviation were found to be 1127, 6.59, and 14.28, respectively. The location of warts was as follows: periungual (n=25; 12.6%), facial - plana (n=16; 8.1%), palmar (n=45; 22.7%), plantar (n=70; 35.4%), and genital (n=42; 21.2%). At clinical recovery evaluation, the recovery rate was 97% (range: 75-100%), and the patient satisfaction was found to be 98.5% in recovery rate over 50%. Our results and the rate of side effects overlap with those in the literature.Conclusion: The treatment success ratio with 1064 nm Nd: YAG laser is quite high in comparison with the other treatment methods and its side effects are not too much, except for pain. Being expensive is the disadvantage of the system. We suggest that Nd: YAG laser is the most efficient and time-saving method in patients with needle fear, unwilling to receive longstanding local treatment, and in children.