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DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF SALBUTAMOL SULPHATE

Keywords: Mucoadhesive , Salbutamol sulphate , Buccal tablet , HPMC , Swelling index , Bioadhesive

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Abstract:

Prime object of present study was to develop and evaluate mucoadhesive tablets of Salbutamol Sulphate by non aqueous granulation of polymers HPMC K-4M (Hydroxypropyl Methyl Cellulose) and Chitosan in different ratios (1:1. 1:2 & 2:1). The tablets were evaluated for weight variation, hardness, thickness, drug content uniformity, mucoadhesion and swelling index. Swelling index of batches containing more HPMC K-4M was greater than that of containing less HPMC K-4M. In vitro bioadhesive strength studies showed that tablets containing more HPMC K-4M were excellent in bioadhesive nature. The in-vitro drug release was studied in phosphate buffer (pH 6.8). And all batches were subjected to release kinetics model fitting.

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