Phytochemical analysis of the dried leaves of Tabernaemontana divaricata (L). (Apocynaceae) indicated the presence of a steroids,tannins, saponins, gums and reducing sugar. The pharmacological interest of these compounds, coupled with the use of this plant in traditional medicine prompted the authors to check for its possible antibacterial activity. The extracts (ethanol, petroleum ether, diethyl ether, methanol and aqueous) were found to possess maximum potency against infectious pathogens Staphylococcus saprophyticus, Staphylococcus aureus, Enterococcus facealis, Staphylococcus pyogenes, Streptococcus agalactae, Salmonella typhi, Escherichia coli, Shigella boydii, Shigella dysenteriae and Pseudomonas aeruginosa. The zone of inhibition was observed with almost all bacteria with some exceptions. Minimum inhibitory concentrations of the extracts were found to be significant. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.