Saraswata Churna is a unique combination of Ayurvedic herbal drugs, containing mainly Medhya Rasayana drugs, like Vacha, Shankhpushpi, Aswagandha, Bramhi, etc. For the first time Saraswata churna is mentioned in Bhavaprakash Unmadadhikar and formula given in the same, selected for present study. The drug is prepared in the Ayurvedic Pharmacy, Institute of Medical Sciences, Banaras Hindu University and was selected for the management of Geriatric Depression. In the clinical study a series of 50 patients of Geriatric Depression were recruited randomly, based on the DSM-IV-TR diagnostic criteria of depression along with their screening for the level of depression using Geriatric Depression Scale (GDS-30). Out of 50, 30 patients were put on Saraswata Churna (Group-A), and 20 patients were on control group, Citalopram (Group-B). The total duration of therapeutic trial was three months. Hamilton Depression Rating Scale (HDRS) has been used to evaluate the response of the drugs. Certain basic biochemical and hematological investigations were also measured before and after the trial. The results have been found to be encouraging with significant relief in the patients belonging to ‘group A’ with no side effects.