Entrepreneurship development is a complex process, which plays long-term and pervasive role in the economical development of the countries. In order to become aware of the level of entrepreneurship, many countries are interested in making comparison between their own experiences and policies and those of others which have been successful in developing entrepreneurship. This study aims at making a comparative investigation of entrepreneurship in Iran and countries of global entrepreneurship monitor. Structural equation modeling was used to study the effect of independent variables of entrepreneurial activities and entrepreneurial perceptions between 2008 until 2010. The results show that entrepreneurial perceptions have a significant effect on entrepreneurial activities and observed variables have a complete positive relationship with each other.