INTRODUCTION: Impacted canines are not uncommon in clinical practice, but intraosseous movement of impacted canines crossing the midline (transmigration) is considered as a rare phenomenon, especially with regard to the mandibular canine. The etiology of transmigration is not clear and early radiographic examination of the patient is of significant importance. AIM: The purpose of this article is to report 4 cases of impacted canine transmigration and review the literature in order to highlight the importance of early detection by panoramic radiographic examination, which may avoid future complications. METHODS: Pretreatment computerized panoramic radiographs.RESULTS: Panoramic radiographic examination of four patients revealed that three patients presented with one impacted transmigrated canine, while the fourth patient with bilateral transmigrated canines. Of the first three transmigrated impacted teeth, the mandibular canine was involved in two instances and the maxillary canine in one instance. Of the three unilateral impacted transmigrated teeth, the left canines were involved. In two cases the transmigrated canine was associated with congenital missing of teeth.CONCLUSION: Migration of the canine through the midline is infrequent and normally asymptomatic. The diagnosis of transmigrated canines is based on the absence of the corresponding permanent canine in the arch as well as on the radiographic findings in both intraoral and panoramic radiographs. Early examination aids in proper treatment planning.