Present study explored the potentials of medicinal plants (Aloe barbedensis, Pimpinella anisum, Berberis lycium, Trigonella foenum-graecum, Allium sativum) mixture in broiler chicks at a ratio of 1:3:1:2:1, respectively. For this purpose 240 chicks were randomly assigned into four major groups, namely; A, B, C and D. Each group was further divided into two subgroups with three replicates of 10 chicks each. One of the subgroups was vaccinated against Newcastle disease (ND), Infectious bronchitis (IB) and Infectious bursal disease (IBD) according to locally adopted vaccination schedule keeping the other subgroup as non vaccinated control. Experimental birds in groups A, B, and C were provided with mentioned infusion @ 20, 10 and 5ml per liter of drinking water while group D was maintained as control. Relevant data were recorded throughout the experiment and or at the termination of the experiment and subjected to statistical analysis. Significantly low mean feed intake (3258.3g) and better FCR (1.87) was recorded in group A. Other parameters like weight gain (1739.7g), antibody titer against ND (7.1), IBD (3300.5) and high density lipoprotein (71.6 g/dl) were significantly increased in chicks from group A. Similarly, blood cholesterol (145.6 g/dl), triglyceride (145.8 g/dl) and low density lipoprotein (57.5 g/dl) were significantly reduced in group A. Overall vaccinated group had higher (P<0.05) antibody titer 7.2, 1796.2, 3202.8 against ND, IB and IBD, respectively compared to non-vaccinated group and had no influence on lipid profile. It was concluded that the infusion from the above plants in mentioned composition may not only be effectively used for improved broiler performance and better immunity but also to reduce the cholesterol level.