In order to find a superdominant gene for yield, a collection of 350 samples with genes mutations and different expression in different phases of growth and development: fruit size, leaf shape, plant architecture, number of fruits, etc., has been studied (through multi-year research). Current seed production at the Institute for Vegetable Crops in Smederevska Palanka includes 26 hybrids and two in acceptation process, of different purposes and characteristics. The most common mutation genes in tomato selection at the Institute are: sp (self-pruning) inbuilt in determinant hybrids (Balkan F1, Marko F1, Rebus F1) and varieties (Narvik SPF, SP-109, Adonis), u (uniform ripening) - Lido F1, Atina F1, Danubius F1, rin (ripening inhibitor)- Nada F1, ampion F1, Sef F1, Sidra F1, Rebus F1, j (jointless) - Narvik, Adonis, SP-109, c (potato leaf) - Mi-13, Enigma F1, Rebus F1, Ph -2 (Phytophtora infestans resistance) - Luna F1, Zlatni jubilej F1, Sef F1. Quality of tomato fruits is defined by two groups of genes which determinate the organoleptic traits and nutrition composition. Organoleptic quality includes taste and smell, colour and texture of fruits established in variety differences, nutritive regime of plants, maturity phase and yield. Little is known about gene regulation, responsible for variation of these traits.