The objective of this study was to examine to what extent functioning of the family system can modulate the effect of conflicts with parents on the levels of family satisfaction of adolescents. The sample (N = 204) was composed of high-school students aged between 15 and 19 years. They responded the Spanish versions of the Family Conflict in Adolescence Scale (Parra & Oliva, 2002; Pérez & Aguilar, 2009), the Family Adaptability and Cohesion Evaluation Scale (FACES-20esp) (Martínez- Pampliega, Iraurgi, Galíndez & Sanz, 2006), and the Satisfaction with Family Life Scale (Luna, Laca & Mejía, 2011). A Multiple Regression analysis showed a significant contribution of Cohesion and Frequency of conflicts on family satisfaction. Based on this, a Univariate Variance Analysis identified that the effect of Frequency of Conflict on Family Satisfaction depends on the degree of family Cohesion. These and other results are discussed in the framework of the controversy present in the literature about the possible positive or negative effects of conflict between parents and children in adolescence.