The anti-anaemic effect of Khaya senegalensis stem bark on phenylhydrazine-induced anaemia was carried out in rats. Induction of anaemia was conducted using phenylhydrazine hydrochloride at a dose of 750 mg kg-1 body weight. In vivo investigation showed that oral daily dose of 300 mg kg-1 body weight of the bark aqueous extract of K. senegalensis in rats administered simultaneously with the phenylhydrazine produced significant (p<0.05) anti-anaemic effect probably by protecting the red blood cells against destruction by phenylhydrazine. However, the same oral dose did not show any significant curative effect (p>0.05) after the induction of anaemia using phyenylhdrazine hydrochloride. The phytochemical screening of the aqueous extract of the stem bark of K. senegalensis indicate the presence of carbohydrate, saponin, glycosides and tannins. Also present are important mineral elements necessary for the development and functioning of the body. These include calcium, magnesium, zinc, iron, copper, potassium, and sodium. This study showed that Khaya senegalensis has an anti-anaemic effect.