Blended learning is a combination of traditional and electronic learning, which utilizes both face-to-face classrooms and information and communication technologies to educate learners. In recent years, blended learning has become a fixed feature within professional educations and has been prioritized by universities around the world, especially medical science universities. Blended learning is being used in medical science education to help improve training in many different areas, including healthcare professionals and students’ education, patients training and global health education. This article discusses blended learning approaches in medical sciences universities. This is a literature review article, which information gathering has been done by using paper and paperless documents related to the topic.