The aim of the present work is to formulate fast dispersible tablets of lactic acid bacillus & Zinc sulphate. In this study, different formulations of fast dispersible tablets were prepared using various excipients & super disintegrants. Different concentrations of crospovidone, cross carmellose sodium & sodium starch glycolate were used as super disintegrants in the formulation of fast dissolution tablet. The powder mass was evaluated for flow properties. All these formulations were prepared by wet granulation method. The tablets were evaluated for hardness, thickness, weight variation, friability, wetting time, disintegration time, and water absorption ratio. Tablets containing crospovidone showed shorter disintegration time i.e. less than 30 sec, comparaed to cross carmellose sodium & sodium starch glycolate hence better patient compliance & effective therapy.