Statement of Problem: Everyday, many people lose their teeth because of various reasons. Knowing the reasons of tooth extraction would help officials to make decisions for helping patients saving their teeth.Purpose: The aim of this study was to investigate the reasons of teeth extraction in dental clinics and some private offices in the city of Kerman in November 2009- February 2010.Materials and Method: In this cross-sectional study, the reasons of teeth extraction in 2076 teeth from 1500 patients selected by simple sampling from Kerman dental clinics were evaluated. Personal data such as gender, age, educational level, occupation, and family size as well as the main reason of tooth extraction (decay, periodontal diseases, prosthesis, tooth impaction, orthodontic reasons, and patient’s request) and the type of tooth were collected by a checklist. Data were analyzed in SPSS, version 11.5 using χ2 test.Results: The two main reasons of tooth extraction were dental caries (43.6%) and patient request (30.6%), respectively. Overall, the first and third molars of the lower jaw were the most commonly extracted teeth. There was a significant relationship between gender and tooth extraction because of caries and orthodontic reasons ( p <0.0001). Meanwhile, the patients’ age had a significant relationship with most teeth extraction reasons ( p <0.0001). Except for patient’s request, educational level had a significant impact on other teeth extraction reasons ( p <0.0001). Conclusion: According to the results of this study, the most common reasons of tooth extraction were dental caries and patient request despite their restorability. Preventive programs and routine dental examination are recommended.