In autumn 2011 we monitored a 5 km long road, paved with cobblestone, situated in Carei Plain Natural Protected Area, a road that is due to be modernized and continued across the border into Hungary. Dead bodies from eight different animal groups were observed on the road, amphibians presenting the greatest amount. The most frequent were the Triturus dobrogicus corps, a species with conservation importance. The amphibians were affected in the areas where the road is neighboring the wetlands, while on the opposite pole sits the area with acacia plantations. The high number of mortalities recorded on the road, despite the low traffic speed, is alarming. It is likely that the modernization of the road that will surely increase its traffic and the speed of the vehicles, will make the situation even worse. However, the rebuilding could contribute to the reduction in the impact on amphibians, if certain measures are considered while planning the action. Thus, in the areas near the wetlands, there should be undercrossings, fences and speed limits. In this way, the modernization would at least represent an experiment regarding the diminution of the road’s impact on amphibians.