Climate change is one of the most important challenges for forestry. Forests are known to be most efficient natural tools to ensure availability and quality of water in many regions. Besides, planning of forest resources towards water quality and quantity is essential in countries that are expected to face with more frequent drought periods in the next decades due to climate change. Watershed management concept has been supposed as the primary tool to plan natural resources in a more efficient and sustainable way by both academicians and practitioners to mitigate and adapt climate change. Forest cover among other land use types provides the best regulating mechanism to mitigate erosion, sedimentation, desertification, and pollution. In addition, climate change can potentially affect forest stand dynamics by influencing the availability of water resources. Therefore, the amount of forest cover in a watershed is an indicator of climate change mitigation and adaptation. Climate change is a concern and risk for the sustainability of water resources in Lakes Region of Turkey. The objective of this study is to make a comprehensive assessment in lake watersheds of the Lakes region considering the forest cover. For this purpose, the study gives a general view of trends in climatic parameters using Mann Kendall trend test. The results showed that Mann Kendall trend test for temperature and precipitation data is not enough to evaluate the magnitude of potential changes of climate in terms of forest cover. Understanding impacts of changes in temperature and precipitation on forest cover, runoff data should be evaluated with temperature and precipitation for watersheds of forest areas in Lakes Region.