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Generation and analysis of expressed sequence tags from the ciliate protozoan parasite Ichthyophthirius multifiliis

INFEC O COM TROFOZOíTOS DE Ichthyophthirius multifiliis (CILIOPHORA) EM Poecilia vivipara (POECILIIDAE) COMO HOSPEDEIRO EXPERIMENTAL INFECTION WITH TROPHOZOITES OF Ichthyophthirius multifiliis (CILIOPHORA) IN Poecilia vivipara (POECILIIDAE) AS AN EXPERIMENTAL HOST

Chemical products for Ichthyophthirius multifiliis, Fouquet (1876) controll in surubim do Igua u Steindachneridion sp., Garavello (1991) Fingerlings / Utiliza o de produtos químicos no controle de Ichthyophthirius multifiliis, Fouquet (1876) em alevinos de surubim do Igua u Steindachneridion sp., Garavello (1991)

Survey of Experimental Contamination to Ichthyophthirius multifiliis in Cultural Rainbow Trout Consequently Vaccination with Aquavac garvetil

Resposta fisiológica à infesta??o experimental com Ichthyophthirius multifiliis (Fouquet, 1876) em alevinos de jundiá (Rhamdia quelen Quoy e Gaimard, 1824) previamente alimentados com diferentes fontes lipídicas

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Using Ciliate Operations to construct Chromosome Phylogenies

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Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control

DOI: 10.1186/gb-2011-12-10-r100

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Abstract:

We report the sequencing, assembly and annotation of the Ich macronuclear genome. Compared with its free-living relative T. thermophila, the Ich genome is reduced approximately two-fold in length and gene density and three-fold in gene content. We analyzed in detail several gene classes with diverse functions in behavior, cellular function and host immunogenicity, including protein kinases, membrane transporters, proteases, surface antigens and cytoskeletal components and regulators. We also mapped by orthology Ich's metabolic pathways in comparison with other ciliates and a potential host organism, the zebrafish Danio rerio.Knowledge of the complete protein-coding and metabolic potential of Ich opens avenues for rational testing of therapeutic drugs that target functions essential to this parasite but not to its fish hosts. Also, a catalog of surface protein-encoding genes will facilitate development of more effective vaccines. The potential to use T. thermophila as a surrogate model offers promise toward controlling 'white spot' disease and understanding the adaptation to a parasitic lifestyle.The ciliates are an ancient and diverse phylogenetic group related to the largely parasitic apicomplexans, but consisting mostly of free-living heterotrophs. Some ciliates, however, have adopted a parasitic lifestyle. By far the most important of these is Ichthyophthirius multifiliis (which we will refer to by its common name of Ich), an endoparasite that causes white spot disease in freshwater fish [1,2]. With an extremely broad host-range, Ich is responsible for large-scale die-offs in natural populations and poses a significant threat to the growing worldwide aquaculture industry. Ich has a simple life cycle with no intermediate hosts (Figure 1). The free-swimming theront form invades the epidermis of susceptible fish, feeding on host tissue and growing up to 0.5 mm in diameter. Host-associated trophonts become visible as individual white spots for which this disease is n

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