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Study of-amyloid adsorption and aggregation on graphite by STM and AFM
Study of β—amyloid adsorption and aggregation on graphite by STM and AFM

Keywords: sanning tunneling microscopy,atomic force microscopy,-amyloid,fibrillization
β-环糊精
,石墨,吸附,聚集,扫描隧道显微镜,原子力显微镜,早老性痴呆,药物载体

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Abstract:

The scanning tunneling microscopy (STM) and the atomic force microscopy (AFM) have been applied to the direct study of the adsorption and aggregation of -amyloid(1-42)(A42) on the hydrophobic graphite surface. It was found that A42 were preferentially adsorbed on graphite defects such as the edges. A42 peptides self-assembled into intermediate protofibrils, which in turn self-associated to form fibrils. Usually, two or more fibrils intertwined to form the helical structure. These results will provide an important clue to studying the aggregation proc-ess of -amyloid.

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