A formula of sensitivity coefficients in porous media is derived from fluid equations by Green's reciprocity principle. The discrete form is given by using numerical integration and finite difference method. The sensitivity coefficients of wellbore pressure to permeability parameters are given by Peaceman's equation and calculated by numerical method of 3D transient anisotropic fluid equation in porous media. The results are verfied by direct method. The computed results are in excellent agreement with those obtained by the direct method.