A well-instrumented field test for the interaction between piles and soils was conducted at a medical technology building of Zhejiang First Hospital. The measured data indicate that the average peripheral and the internal earth pressure account for 83.3% and 62.7% of the characteristic value of soil bearing capacity respectively,when the decoration period is completed,suggesting that the bearing capacity of the soil beneath the foundation slab is utilized to a greater degree. During decoration period,the measured average reaction force at pile top is more than 50% of the ultimate bearing capacity of a single pile,differing from a single pile in the traditional design situation. Moreover,the percentage of the total load shared by the soils gradually decreases with increasing load and reaches about 20% at the completion of decoration period. In addition,the measured average compressive steel stresses of surface and bottom base plate are very small,about 9.84 MPa and 7.68 MPa at the completion of this building respectively. These measured data are far lower than the ultimate compressive stress of the steel bar. At the same load level at the pile head,the measured shaft resistance of a foundation pile is less than that of a single pile in static load test because of the weakening effect of the foundation slab on the shaft resistance. Finally,the measured results show that the settlement of this building is small and uniform,satisfying the operation requirements.