Ipomoea pes-caprae is a medicinal plant used in many countries for the treatment of several ailments including inflammatory and algesic processes. The present study describes the antimicrobial, hemolytic, analgesic and anti-inflammatory effects of the methanolic extract obtained from flower parts of this plant. The results indicated that the methanolic extract) exhibited considerable antinociceptive activity against two classical models of pain in mice. Methanolic extract presented a calculated the value of 5 and 2 mg kg-1 of body weight, i.p. against tail flick test and also inhibited both phases of pain (tail flick and hot plate). The maximum for paw licking Aanalgesic Rresponse (AR) was recorded 4 in crude extract of Ipomoea pes-caprae flower extract after 45 min of administration and minimum of 1 AR showed 30 and 45 min after administration whereas minimum of 3 AR was recorded in 60 min, respectively. The methanolic extracts exhibited the considerable antimicrobial activity against human bacterial and fungal pathogens. Preliminary phytochemical analysis suggested the presence of steroids, terpenoids, alkaloids and flavonoids. These findings support, at least in part, the popular use of I. pes-caprae to treat dolorous processes.