Flow duration curves are simple and powerful tools to deal with many hydrological and environmental problems related to water quality assessment, water-use assessment and water allocation. Unfortunately the scarcity of streamflow data enables the use of these instruments only for gauged basins. A regional model is developed here for estimating flow duration curves at ungauged basins in Sicily, Italy. Due to the complex ephemeral behavior of the examined region, this study distinguishes dry periods, when flows are zero, from wet periods using a three parameters power law to describe the frequency distribution of flows. A large dataset of streamflows has been analyzed and the parameters of flow duration curves have been derived for about fifty basins. Regional regression equations have been developed to derive flow duration curves starting from morphological basin characteristics.