The objective of the BRAHMATWINN research component described in this chapter is to develop integrated indicators with relevance to Integrated Water Resources Management (IWRM) and climate change for the Upper Danube and the Upper Brahmaputra River Basins (UDRB and UBRB), and to foster the integration process amongst the different research activities of the project. Such integrated indicators aim at providing stakeholders, NGOs and GOs with an overview of the present state and trends of the river basins water resources, and at quantifying the impacts of possible scenarios and responses to driving forces, as well as pressures from likely climate change. In the process the relevant indicators have been identified by research partners to model and monitor issues relevant for IWRM in the case study areas. The selected indicators have been validated with the information gathered through the NetSyMoD approach (Giupponi et al., 2008) in workshops with local actors. In this way a strong link between the main issues affecting the basins as perceived by local actors and the BRAHMATWINN activities has been created, thus fostering integration between research outcomes and local needs.