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Preliminary Investigation for Immunomodulation of Methanolic Extracts of Leaves and Flowers of Pongamia Glabra Vent. in Mice Model

DOI: 10.5923/j.als.20120206.04

Keywords: Pongamia Glabra Vent., Cyclophosphamide, Immunomodulatory, Myelosuppression

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Abstract:

Evaluation of the immunomodulatory activity methanolic extracts of leaves and flowers ofPongamia glabra Vent. in cyclophosphamide induced myelosuppressed mice. Methanolic extracts of leaves and flowers of Pongamia glabra Vent. at the doses of 250mg/kg and 500mg/kg p.o. were administered for 13 days to normal adult albino mice of either sex and cyclophosphamide (30mg/kg i.p.) was injected on 11th,12th and 13th days 1 hour after the administration of the treatment with extract. On 14th day blood was collected by retro orbital puncture and the activity was evaluated by determining the RBC, Hb%, Platelet, total WBC and differential counts. Methanolic extracts of leaves and flowers of Pongamia glabra Vent. showed dose dependant highly significant(p<0.001) counteracting effect to cyclophosphamide induced reduction in total WBC, DLC and platelet counts and significant (p<0.01) effect to that of reduction in RBC counts and Hb%. The significant immunostimulant activity of the methanolic extracts of Pongamia glabra Vent. leaves and flowers at the doses of 250mg/kg and 500mg/kg p.o. in cyclophosphamide induced myelosuppression may be attributed towards the presence of bioactive components, viz.- saponins, sterols, tannins and flavonoids in the extracts.

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