imal electrocardiographic limb lead set for rapid emphysema screening Original Research (1686) Total Article Views Authors: Bajaj R, Chhabra L, Basheer Z, Spodick DH Published Date January 2013 Volume 2013:8 Pages 41 - 44 DOI: http://dx.doi.org/10.2147/COPD.S37776 Received: 05 September 2012 Accepted: 21 December 2012 Published: 20 January 2013 Rishi Bajaj,1 Lovely Chhabra,1 Zainab Basheer,2 David H Spodick3 1Department of Internal Medicine, University of Massachusetts Medical School, Worcester, MA, USA; 2Department of Medicine, Al Ameen Medical College, Karnataka, India; 3Department of Cardiovascular Medicine, Saint Vincent Hospital, University of Massachusetts Medical School, Worcester, MA, USA Background: Pulmonary emphysema of any etiology has been shown to be strongly and quasidiagnostically associated with a vertical frontal P wave axis. A vertical P wave axis (>60 degrees) during sinus rhythm can be easily determined by a P wave in lead III greater than the P wave in lead I (bipolar lead set) or a dominantly negative P wave in aVL (unipolar lead set). The purpose of this investigation was to determine which set of limb leads may be better for identifying the vertical P vector of emphysema in adults. Methods: Unselected consecutive electrocardiograms from 100 patients with a diagnosis of emphysema were analyzed to determine the P wave axis. Patients aged younger than 45 years, those not in sinus rhythm, and those with poor quality tracings were excluded. The electrocardiographic data were divided into three categories depending on the frontal P wave axis, ie, >60 degrees, 60 degrees, or <60 degrees, by each criterion (P amplitude lead III > lead I and a negative P wave in aVL). Results: Sixty-six percent of patients had a P wave axis > 60 degrees based on aVL, and 88% of patients had a P wave axis > 60 degrees based on the P wave in lead III being greater than in lead I. Conclusion: A P wave in lead III greater than that in lead I is a more sensitive marker than a negative P wave in aVL for diagnosing emphysema and is recommended for rapid routine screening.