ggressive behavior, cognitive impairment, and depressive symptoms in elderly subjects Original Research (17250) Total Article Views Authors: Margari F, Sicolo M, Spinelli L, Mastroianni F, Pastore A, Craig F, Petruzzelli MG Published Date August 2012 Volume 2012:8 Pages 347 - 353 DOI: http://dx.doi.org/10.2147/NDT.S33745 Received: 09 May 2012 Accepted: 12 June 2012 Published: 01 August 2012 Francesco Margari,1 Michele Sicolo,1 Lucia Spinelli,1 Franco Mastroianni,2 Adriana Pastore,1 Francesco Craig,3 Maria Giuseppina Petruzzelli3 1Psychiatry Unit, Department of Neuroscience and Sense Organs, Hospital Polyclinic of Bari, University of Bari “Aldo Moro”, 2Geriatrics Unit, Hospital “Miulli”, Acquaviva delle Fonti; 3Child Neuropsychiatry Unit, Department of Neuroscience and Sense Organs, University of Bari “Aldo Moro,” Bari, Italy Abstract: Patients with dementia often have neuropsychiatric symptoms. The objective of this study was to evaluate the relationship between neuropsychiatric symptoms and progressive cognitive decline by assessing cognitive impairment, depressive symptoms, and aggressive behavior in a sample of elderly subjects. The study sample consisted of 201 subjects admitted to nursing homes. For the purpose of the present study each subject was evaluated using the Mini-Mental State Examination, the Geriatric Depression Scale, and the Modified Overt Aggression Scale. The results show that aggressive behavior and depressive symptoms are associated with progressive cognitive decline in elderly subjects. Early assessment of these conditions can promote rational therapeutic strategies that may improve the quality of life and delay institutionalization for elderly patients.