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PLOS ONE  2012 

The Role of Histone H4 Biotinylation in the Structure of Nucleosomes

DOI: 10.1371/journal.pone.0016299

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Abstract:

Post-translational modifications of histones play important roles in regulating nucleosome structure and gene transcription. It has been shown that biotinylation of histone H4 at lysine-12 in histone H4 (K12Bio-H4) is associated with repression of a number of genes. We hypothesized that biotinylation modifies the physical structure of nucleosomes, and that biotin-induced conformational changes contribute to gene silencing associated with histone biotinylation.

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