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Clinical evaluation of a new multi-purpose disinfecting solution in symptomatic wearers of silicone hydrogel contact lenses

DOI: http://dx.doi.org/10.2147/OPTO.S31341

Keywords: multi-purpose disinfecting solution, subjective comfort, silicone hydrogel contact lenses

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Abstract:

ical evaluation of a new multi-purpose disinfecting solution in symptomatic wearers of silicone hydrogel contact lenses Original Research (1424) Total Article Views Authors: Corbin GS, Kading DL, Powell SM, Rosenblatt BD, Secor GB, Maissa CA, Garofalo RJ Published Date July 2012 Volume 2012:4 Pages 13 - 24 DOI: http://dx.doi.org/10.2147/OPTO.S31341 Received: 01 March 2012 Accepted: 19 April 2012 Published: 26 July 2012 Glenn S Corbin,1 David L Kading,2 Sean M Powell,3 Brian D Rosenblatt,4 Glenda B Secor,5 Cecile A Maissa,6 Renee J Garofalo7 1Wyomissing Optometric Center, Wyomissing, PA, USA; 2Specialty Eyecare Group, Kirkland, WA, USA; 320/20 Eye Care LLC, Lenexa, KS, USA; 4Rosenblatt Family Eye Care Associates, Raritan, NJ, USA; 5Huntington Beach, CA, USA; 6OTG Research and Consultancy, London, UK; 7Alcon Research Ltd, Fort Worth, TX, USA Background: The purpose of this study was to evaluate the safety and efficacy of a new multi-purpose disinfecting solution containing a diblock copolymer, poly(oxyethylene)-poly(oxybutylene), designed to improve the wetting properties of silicone hydrogel lenses in patients with symptoms of discomfort. Methods: This 30-day, randomized, concurrently controlled, double-masked, multi-site study involved 589 subjects at 42 investigational sites in the US. Existing symptomatic lens wearers were randomly assigned to either regimen 1 (OPTI-FREE PureMoist , Alcon Laboratories Inc,) a newly developed formulation containing the diblock copolymer), or regimen 2 (renu fresh multi-purpose solution Bausch + Lomb, Inc). On days 0, 14 and 30, subjects assessed acceptability and comfort using seven Likert-type questions, rated the intensity of ocular symptoms (comfort, dryness, irritation, scratchiness, burning, stinging) on a visual analog scale (0–100), as well as reported lens wearing time, comfortable lens wearing time, and rewetting drop frequency. The investigators assessed slit-lamp findings (including circumlimbal conjunctival lissamine green staining and corneal fluorescein staining), on-eye lens surface wettability and deposits, visual acuity, and adverse events. Results: Differences favoring regimen 1 were noted on Day 30 for the primary Likert statement “I can comfortably wear my lenses” (P = 0.047) and for comfortable lens wear time (P = 0.041). Symptoms of ocular scratchiness, ocular burning, and ocular stinging were all rated lower after 30 days of use by subjects using regimen 1 compared with those using regimen 2 (P ≤ 0.024). Circumlimbal conjunctival staining (sum score) was significantly lower with regimen 1 (P < 0.0001). Other parameters did not show any difference between the two treatment regimens. Conclusion: This study shows that the new multi-purpose disinfecting solution is safe and effective when used by symptomatic silicone hydrogel contact lens wearers. By improving symptoms of scratchiness, burning, stinging, and comfortable wear time, and decreasing circumlimbal conjunctival staining, the new m

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