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Prussian blue as an antidote for radioactive thallium and cesium poisoning

DOI: http://dx.doi.org/10.2147/ODRR.S31881

Keywords: Prussian blue, radioactive cesium, thallium, intoxication, biodefense drug

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Abstract:

ussian blue as an antidote for radioactive thallium and cesium poisoning Review (1591) Total Article Views Authors: Altagracia-Martinez M, Kravzov-Jinich J, Martínez-Nú ez JM, Ríos-Casta eda C, López-Naranjo F Published Date June 2012 Volume 2012:2 Pages 13 - 21 DOI: http://dx.doi.org/10.2147/ODRR.S31881 Received: 17 March 2012 Accepted: 16 April 2012 Published: 08 June 2012 Marina Altagracia-Martínez, Jaime Kravzov-Jinich, Juan Manuel Martínez-Nú ez, Camilo Ríos-Casta eda, Francisco López-Naranjo Departments of Biological Systems and Health Care, Biological and Health Sciences Division, Universidad Autónoma Metropolitana-Xochimilco, Mexico DF, Mexico Background: Following the attacks on the US on September 11, 2001, potentially millions of people might experience contamination from radioactive metals. However, before the specter of such accidents arose, Prussian blue was known only as an investigational agent for accidental thallium and cesium poisoning. The purpose of this review is to update the state of the art concerning use of Prussian blue as an effective and safe drug against possible bioterrorism attacks and to disseminate medical information in order to contribute to the production of Prussian blue as a biodefense drug. Methods: We compiled articles from a systematic review conducted from January 1, 1960 to March 30, 2011. The electronic databases consulted were Medline, PubMed, the Cochrane Library, and Scopus. Results: Prussian blue is effective and safe for use against radioactive intoxications involving cesium-137 and thallium. The US Food and Drug Administration has approved Prussian blue as a drug, but there is only one manufacturer providing Prussian blue to the US. Based on the evidence, Prussian blue is effective for use against radioactive intoxications involving cesium-137 and thallium, but additional clinical research on and production of Prussian blue are needed.

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