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Liquisolid tablets: a novel approach for drug delivery

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Abstract:

Liquisolid system is a novel concept of drug delivery via oral route. This technique is applied to water insoluble drugs and lipophilic drugs to sustain their release. Formulation and manufacture of the liquisolid tablets is quite simple method according to new mathematical model described by Spireas et al. It involves dissolving the drug in suitable non-volatile solvent and then adding this liquid medication to the mixture of carrier and coating materials. Mixing of this will lead to liquisolid system which is subjected to tabletting by direct compression. Increase in dissolution rate and in turn improvement in bioavailability is observed in case of poorly water soluble drugs. However, sustained effect is achieved in case of water soluble drugs. By use of this technique, liquid medications such as solutions or suspensions of water insoluble drugs in suitable non-volatile liquid vehicles can be easily converted into powder with acceptable flow properties and compression behavior using suitable powder excipients.

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