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Association of β-fibrinogen gene 148C/T and 455G/A polymorphisms and coronary artery disease in Chinese population: A Meta analysis

DOI: 10.1007/s11427-008-0102-0

Keywords: β-fibrinogen,gene polymorphism,coronary artery disease,myocardial infarction,Meta-analysis

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Abstract:

The purpose of our study was to evaluate the correlation between the β-fibrinogen gene 148C/T and 455G/A polymorphisms and susceptibility to coronary artery disease in the Chinese population using a meta-analytic approach. Eligible studies about this correlation were identified by searching the PubMed, EMBASE, and CNKI databases. Of the 13 identified, 7 (with 1488 cases and 1234 controls) involved the 148C/T polymorphism and 9 (with 1023 cases and 1081 controls) involved the 455G/A polymorphism. No publication bias was detectable and heterogeneity testing found significant differences between the ORs for both groups of studies. The combined OR for the 7 studies on susceptibility to coronary artery disease in 148T allele carriers compared to the 148C/C wild-type homozygotes was 1.31 (95%CI: 0.94–1.84, P=0.11). The combined OR for the 9 studies on susceptibility to coronary artery disease in 455A allele carriers compared to the 455G/G wild-type homozygotes was 1.75 (95%CI: 1.24–2.46, P=0.001). Our results suggest the absence of an association between the β-fibrinogen gene 148C/T polymorphism and susceptibility to coronary artery disease and the possibility that 455G/A polymorphism (in particular, allele A) increases susceptibility to this disease in the Chinese population.

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