introduction: the amazon region of brazil is endemic for malaria. in the state of santa catarina, malaria was eliminated in the 1980s. since then, a few sporadic isolated autochthonous cases have occurred. however, because malaria vectors are present within brazilian territory and extensive endemic areas exist in this country, along with the great mobility of people in tourist areas of santa catarina, there is the likelihood of reintroduction of the disease. methods: the following data were used: the database of the entomology group of the national health foundation, santa catarina (acces, 1997-2000); the epidemiological surveillance information system of the health surveillance department (malaria/sc); and the notifiable disease information system (sinan/sc). these data were transferred to and analyzed in the microsoft office excel 2007 software. results: collections were carried out in 48 municipalities and 159 localities, and 12,310 culicids, 11,546 anophelines (93.7%) and 764 others (6.2%) were identified. three subgenera and 13 species of anophelines were identified. conclusions: given that in the municipalities investigated, important vectors such as anopheles cruzii and anopheles albitasis were found to be present, with movements of infected individuals from endemic areas, these areas can be considered to be receptive and vulnerable to malaria. these species are suspected of being responsible for malaria transmission in this region, especially in the municipalities of gaspar, indaial and rodeio.