gastroesophageal reflux (ger) is common in infants during the early months of life, as a result of a weak development of the regulatory mechanisms. nevertheless, ger tends to disappear as infants grow. nowadays, ger has become a common cause ofpediatric consultation in the clinical practice, especially if it is followed by vomits. sometimes, changing baby position while feeding seems to be a solution to reduce symptoms, while other times it is necessary manage the problem according to clinical practice guidelines. in these guidelines, the use of anti-regurgitation infant formulas are included, which has been formulated with thickening agents and/or whey/casein ratio modification. antiregurgitation milk products are available without pediatric prescription in chemists and other authorized establishments. published studies on antiregurgitant infant formulas show some contradictory conclusions about their use. a negative effect on mineral and micronutrient bioavailability has been proposed by some authors, in relation to the presence of thickening agents used as ingredients. different aspects which require more research, related to the use of antiregurgitation infant formulas, have been included in this review with the aim ofproducing more effective and safety products for an especially vulnerable population, where an optimum feeding will lead to an adequate development and good health status in the future.