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Avalia??o da mutagenicidade e antimutagenicidade de um biopolímero extraído do microorganismo Agrobacterium radiobacter em camundongos Swiss

DOI: 10.1590/S0102-695X2010000300009

Keywords: curdlana, biopolymer, agrobacterium radiobacter, β-glucan, antimutagenic, swiss mice.

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Abstract:

this study evaluated the mutagenic and ant mutagenic action of a biopolymer of glucose extracted from agrobacterium radiobacter (biopolymer of agrobacterium radiobacter). the experiment was conducted with swiss male mice divided into eight groups. treatment with the biopolymer was performed in a single dose by gavage at a dose of concomitant phosphate buffer groups in the evaluation of mutagenicity, or the agent of inducing dna damage, cyclophosphamide, the concentration of 50 mg/kg (body weight --b.w.), in groups of assessment ant mutagenic. we used the micronucleus test in peripheral blood. the blood sample was held 24 and 48 h after application of the test substances. statistical analysis showed that the biopolymer has no mutagenic activity and it is effective in preventing damage to dna. the percentages of damage reduction in groups of ant mutagenic were 83.9%, 89.1% and 103.1% in 24 h and 101.24%, 98.14% and 120.64% at doses of 48 to 75, 150 and 300 mg/kg (b.w.) respectively. the high percentage of damage reduction associated with the absence of mutagenic effects indicates the possibility of biopolymer chemoprotection action. it can also be considered a functional food candidate to be used as co-adjuvant chemotherapy to prevent side effects.

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