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Jul 21, 2023Open Access
Atopic dermatitis is a chronic and inflammatory skin disease and the most severe forms could strongly impact the patient’s quality of life. Skin barrier dysfunction is considered the first step in the atopic march. RNF31 deficiency significantly changes the skin structure and increases its thickness. The keratinocytes show decreased expression of K10 and loricrin. In this way, RNF31 deficiency alters the proper functioning of the skin by altering the homeostasis of keratinocytes. W...
Aug 20, 2021Open Access
The network pharmacology and molecular docking technology were used to elucidate the mechanism of Artemisiae scopariae Herba (ASH) against liver cancer (LC). TCMSP and UniProt database were used to collect the active ingredients of ASH and predict their potential targets. The targets of LC were screened by GeneCards, OMIM and TTD database. The intersections of drug and disease targets were obtained by online software Venny 2.1, and the intersection targets were imported into R software (v3.6.3) ...
Mar 05, 2021Open Access
This is a detailed experimental and comparative study evaluating the harmful effects of graded loud noise on hematological and antioxidant in Wistar albino rats. Wistar albino rats were divided into a control group (those kept away from the noise due to a generator set), groups 1 (exposed to varied, 85 - 105 db levels of loud noise from a generator) and groups 2 (exposed to less, 40 - 55 db levels of loud noise from generator set) and exposed to way off fumes from electrical generator sounds at ...
Sep 22, 2020Open Access
Cytogenetics plays a major role in Cancer studies, as some abnormalities aid in the correct categorizing of leukemia and lymphomas, and additionally provides important prognostic information. Though every laboratory follows SOP’s, there is always a chance of culture failure. We processed and analyzed 36 BMA (Bone marrow aspirate) and 31 PB samples (Peripheral blood) with referral reasons: Acute lymphoblastic leukemia (ALL) n = 37, Chronic lymphocytic leukemia (CLL) n = 7, Acute myeloid leukemia ...
Sep 30, 2019Open Access
Lipoma is the most common soft tissue tumor, considered the universal tumor in the body. The differential diagnosis of a lipoma in the groin will include groin hernias, safina varex, lymphadenopathy, hydrocele and sarcoma. Due to the similarity of clinical symptoms and signs, the differentiation between inguinal, femoral hernias and groin lipoma is difficult. To avoid the high risk of intraoperative complica ...
Jun 30, 2017Open Access
Objective: To observe the therapeutic effects of
acupuncture for treatment of different stages of Acute Bell’s palsy, and its
relationship to age and sex. Patients and Methods: 152 patients of Bell’s
palsy, were acute cases in different grade of paralysis. Following up with
combined drugs and acupuncture therapy for one month, which were diagnosed
clinically and proved by electromyography EMG, these cases of acu ...
Nov 25, 2016Open Access
The
single nucleotide polymorphism (SNP) rs4731702 in the KLF14 transcription factor gene has
been associated with type 2 diabetes mellitus (T2DM) and HDL-c concentrations. The aim of the present study was to
determine the distribution of KLF14
rs4731702 SNP and evaluate the association betwee ...
Oct 23, 2014Open Access
Introduction:
Type 2 Diabetes Mellitus (T2DM) is a complex disorder caused by the interaction
between genetic predisposition and environmental factors. Genetics plays an important
role on lipid homeostasis. Many genes are involved in the lipid metabolism, such
as FABP-2 and PPAR- γ. Aim: To evaluate
the association between specific SNPs and haplotypes of the FABP-2 and PPAR- γ genes with T2DM and lipid profile in an
Argentinean population. Methods: The FABP-2 (rs1799883)
and PPAR- ...
Jun 18, 2014Open Access
Asthma is a chronic inflammatory disease of the airways manifested by
reversible airflow obstruction and airway hyperresponsiveness. While recent
research has mapped several genes as possible factors predisposing to asthma,
interleukin-13 remains one of the most commonly found genes in various
populations. IL-13 is a pleiotropic TH2 cytokine which has been linked to cause
an increase in goblet cell differentiation, activation of fibroblasts,
elevation of bronchial hyperresponsiveness and s...
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