OALib 期刊
  OALib Journal (ISSN Print: 2333-9705, ISSN Online: 2333-9721)是一本多合一的开源期刊,以同行评审的方式出版发行文章,其所涵盖的研究领域多达311种领域。本刊发表的全部文章均可在期刊网站上免费阅读、下载、引用和传播。单篇文章出版费用为99美元。详情请咨询service@oalib.com现在就去投稿!
               文章 | 目标与领域 | 读者指南 | 编委 | 文章版面费检索             


Go

Mar 14, 2017Open    AccessArticle

Cell-Cycle-Associated Amplified Genomic-DNA Fragments (CAGFs) Might Be Involved in Chloroquine Action and Resistance in Plasmodium falciparum

Gao-De Li
As a cheap and safe antimalarial agent, chloroquine (CQ) has been used in the battle against malaria for more than half century. However, the mechanism of CQ action and resistance in Plasmodium falciparum remains elusive. Based on further analysis of our published experimental results, we propose that the mechanism of CQ action and resistance might be closely li
...


Feb 15, 2017Open    AccessArticle

UV Visible Spectrophotometric Determination of the Quality of Antiretroviral Drugs Distributed in Kinshasa

Erick Ntambwe Kamangu, Jérémie K. Mbinze, Arnold M. Mingu, Jacquie B. Bolavie, Georges Lelo Mvumbi, Richard Lunganza Kalala, Gauthier Kahunu Mesia, Mariano Lusakibanza, Jean Mavar, Roland D. Marini
Background: Antiretrovirals (ARVs) are the molecules used in the fight against infection by the Human Immunodeficiency Virus (HIV). Their main objective is to stop the virus from replicating and thus allow the immune system to recover. In 2001, the program to fight against HIV/AIDS United Nations (UNAIDS) and its partners has decided to strengthen the pharmaceutical channel and improve access to good quality
...


Feb 09, 2017Open    AccessArticle

Methods for Non-Destructively Separating or Reannealing the Strands of Circular Duplex DNA Chromosomes

Ken Biegeleisen
Although it is not widely-known, the strands of circular duplex plasmid and viral chromosomes have been non-destructively separated, and the separated strands have been reconstituted to yield a new duplex structure with all the properties of the native chromosome restored. This suggests a paranemic structure for the DNA, that is, a structure whose strands are no
...


Oct 26, 2016Open    AccessArticle

The Probable Structure of “Form IV” (Alkali-Denatured Circular DNA)

Ken Biegeleisen
A detailed molecular model for alkali-denatured duplex circular DNA (“Form IV”) is proposed. The illustrative biological example used is the replicative form of fx174, a 5 kb duplex circular chromosome. The model explains all of Form IV’s known and peculiar features. In a sedimentation coefficient vs. pH titration, Form IV begins to appear at pH 12.3, at which point it can be persuasively argued that no further supertwists can be
...


Aug 17, 2016Open    AccessArticle

Genoautotomy (Genome 'Self-Injury') in Eukaryotic Cells: A Cellular Defence Response to Genotoxic Stress

Gao-De Li
This paper proposes that eukaryotic cells, under severe genotoxic stress, can commit genoautotomy (genome “self-injury”) that involves cutting and releasing single-stranded DNA (ssDNA) fragments from double-stranded DNA and leaving ssDNA gaps in the genome. The ssDNA gaps could be easily and precisely repaired later. The released ssDNA fragments may play some role in the regulation of cell cycle progression. Taken together, genoau
...


Jun 17, 2016Open    AccessArticle

A Possible Mechanism of DNA to DNA Transcription in Eukaryotic Cells: Endonuclease Dependent Transcript Cutout

Gao-De Li
We previously proposed the existence of DNA to DNA transcription in eukaryotic cells, but the mechanism by which single-stranded DNA (ssDNA) transcript is produced and released from the genome remains unknown. We once speculated that the mechanism of DNA to DNA transcription might be similar to that of DNA to RNA transcription, but now we propose that endonuclease dependent transcript cutout may be a possible mechanism of DNA to D
...


Jun 13, 2016Open    AccessArticle

Applications of Nanotechnology in Reconstructive Surgery

Timothy Varghese
The objective of this review was to critically present and evaluate recent investigations into nanotechnology and it’s applications in reconstructive surgery. In addition, this review aims to looks at a plethora of applications with nanotechnology in the subject area of reconstructive surgery. The Medline and PubMed databases were searched for clinical trial and case report publications dealing with reconstructive surgeries involv
...


May 17, 2016Open    AccessArticle

DNA to DNA Transcription Might Exist in Eukaryotic Cells

Gao-De Li
Till now, in biological sciences, the term, transcription, mainly refers to DNA to RNA transcription. But our recently published experimental findings obtained from Plasmodium falciparum strongly suggest the existence of DNA to DNA transcription in the genome of eukaryotic cells, which could shed some light on the functions of certain noncoding DNA in the human
...


Apr 18, 2016Open    AccessArticle

“Natural Site-Directed Mutagenesis” Might Exist in Eukaryotic Cells

Gao-De Li
Site-directed mutagenesis refers to a man-made molecular biology method that is used to make genetic alterations in the DNA sequence of a gene of interest. But based on our recently published experimental findings, we propose that “natural site-directed mutagenesis” might exist in eukaryotic cells, which is triggered by harmful agents and co-directed by special transcription hotspots and mutation-contained intranuclear primers.


Mar 25, 2016Open    AccessArticle

Physicochemical and Proximate Analysis of Extracts from Citrus sinensis of Dutsinma, Katsina State, Nigeria

Gnimintakpa Joseph, Sa’ada Abdullahi
This paper performed the physicochemical and proximate analysis of the extracts isolated from Citrus sinensis from Dutsinma local government area of Katsina state in Nigeria. Characteristics of the seeds were investigated by Association of Official Analytical Chemists (AOACs). The seeds were found to be potential raw materials for livestocks nutrition, cosmetic manufacturing and construction industries. The physicochemical parameters included oil percentage yield, melting point, specific ...


Go