%0 Journal Article
%T Assessing the Effect and Use of an Aqueous Form of a Common Ghanaian Leaves Extract, <i>Chromolaena odorata</i> (Acheampong Leaf) on Coagulation Test Parameters <i>in Vitro</i>
%A David Ntiamoah Ofosu
%A Akwasi Asamoah
%A Ransford Mawuli Tuekpe
%A Edmond Opoku Addo
%A Elijah Kofi Takyi
%A Alex Addai
%J Open Access Library Journal
%V 10
%N 1
%P 1-12
%@ 2333-9721
%D 2023
%I Open Access Library
%R 10.4236/oalib.1109611
%X Background: In Ghana, the use of <i>Chromolaena odorata</i> (Acheampong Leaf) as a first aid material to control bleeding is a very common practice in the rural areas. This study sought to assess the coagulation effect of aqueous extract of <i>C. odorata</i> (Acheampong Leaf) leaves on the coagulation profile. Methods: In this experimental study, freshly obtained <i>C. odorata</i> leaves extract was made using distilled water. Blood samples were taken from 197 non-hemophiliacs. PT and aPTT tests were tested with the extract. Results: The study result showed significantly reduced PT results of the study participants (17.89 ¡À 3.06 s to 16.43 ¡À 2.51 s, p < 0.0001) but no effect was recorded with aPTT (38.83 ¡À 7.13 s against 39.12 ¡À 7.85, p = 0.709). Conclusion: <i>C. odorata</i> proved to be strongly effective in promoting coagulation (procoagulant) <i>in vitro</i>. We recommend studies to isolate and purify the active chemical compound in <i>C. odorata</i> leaves to further the pathway and mechanism of action.
%K C. odorata
%K Acheampong Leaf
%K Prothrombin Time
%K Activated Partial Thromboplastin Time
%U http://www.oalib.com/paper/6786695