%0 Journal Article
%T The Role of Autophagy in Acute Myeloid Leukemia
%A Siyu Zhou
%A Yu Wu
%A Yili Cai
%A Zecheng Yu
%A Ruirui Li
%A Chunwei Yan
%A Fangwei Dai
%A Wei Han
%J Open Access Library Journal
%V 9
%N 12
%P 1-13
%@ 2333-9721
%D 2022
%I Open Access Library
%R 10.4236/oalib.1109476
%X Autophagy is an important biological mechanism to transport proteins in organelles to lysosome for degradation, maintaining a stable physiological balance of the body. Acute Myeloid Leukemia (AML) refers to hematological malignancy caused by a disorder of myeloid hematopoietic stem cells. Recent studies have shown that the expression of some autophagy-related genes in AML patients is closely related to the prognosis and leukocyte formation of AML patients. Therefore, we can use autophagy as a potential target for monitoring, prognosis, and molecular diagnosis of leukemia patients. The study summarized the interaction between AML and autophagy-related signal pathways (such as mTOR and PI3K pathway) and explained the influence of related inhibitors and activators on AML cells in recent years, which laid a theoretical foundation for clinical treatment and research development of AML patients.
%K Autophagy
%K Acute Myeloid Leukemia
%K Signaling Pathway
%K Clinical Treatment
%U http://www.oalib.com/paper/6784396