%0 Journal Article
%T Teratogenic Investigation of Bay Leaf (<i>Syzygium polyanthum</i> Wight.) Ethanol Extract on Morphology of Fetal Mice (<i>Mus musculus</i> L.) Strain DDY
%A Marissa Angelina
%A Aulia Ovy
%A Indah D. Dewijanti
%A Ainul Mardhiyah
%A Luthfiralda Sjahfirdi
%J Open Access Library Journal
%V 9
%N 4
%P 1-13
%@ 2333-9721
%D 2022
%I Open Access Library
%R 10.4236/oalib.1108385
%X This research was conducted to observe the teratogenic potential of <i>S. polyanthum</i> ethanol extract on morphology of fetal mice strain DDY. Thirty pregnant female mice were divided into 5 groups, normal group and treatment groups with dose 0.5; 5; 50; 500 mg/bw. The extract was given orally from 6th to 15th day of gestation. The results showed that the effect of <i>S. polyanthum</i> ethanol extract at a dose of 0.5 mg/bw did not cause resorption and external malformation. At a dose of 5 mg/bw, there were resorption (6.15%) and fetal open eyelids (1.63%). Resorption (7.69%; 9.34%) and fetal hemorrhage (1.63%; 1.47%) were found in mice given doses of 50 and 500 mg/bw. The treatment of <i>S. polyanthum</i> ethanol extract at doses 0.5; 5; 50; 500 mg/bw during the period of organogenesis did not have a significant influence on morphology of fetal mice strain DDY (p > 0.05).
%K Fetus
%K Mice
%K Organogenesis
%K Resorption
%K S. polyanthum
%U http://www.oalib.com/paper/6769316