%0 Journal Article
%T Effect of Granules Size on the Release Kinetics of Ibuprofen from Its Matrix Tablet
%A Ekaete I. Akpabio
%A Daniel E. Effiong
%A Timma O. Uwah
%A Sabinus I. Ofoefule
%J Open Access Library Journal
%V 9
%N 2
%P 1-15
%@ 2333-9721
%D 2022
%I Open Access Library
%R 10.4236/oalib.1107920
%X Background: Sustained-release matrix tablets have been used to present a wide range of drugs for oral use. Matrix tablets are formed by compaction of drug granules prepared by granulation of drug-polymer mix. Objective: This study was to evaluate different granule sizes of ibuprofen produced using two polymers and determine whether granule size and polymer type influenced Ibuprofen release from the sustained-release matrix tablets. Method: Ethyl cellulose and Carbopol 940 were used separately at a concentration of 20% to prepare ibuprofen granules. Dried granules were sieved into sizes; 0.25, 0.5, 1 and 2 mm respectively. Compatibility studies were carried out using FT-IR and DSC. The micromeritics of batches of the different sizes of granules and physico-mechanical properties of tablets formed were evaluated. The dissolution profiles were assessed <i>in-vitro</i> using enzyme-absent phosphate buffer for 8 hours. Drug percentage release was fitted into release kinetic models so as to describe drug release pattern and mechanism. Results: Swelling index in both polymers increased with granule size. All tablets passed mechanical tests of crushing strength and friability (with ranges of 6.2 - 8.6 KgF and 0.4% - 0.9% respectively). For the Ethyl cellulose matrix tablet, E1 followed first order (R<sup>2</sup> = 0.987), but E<sub>2</sub> and E<sub>3</sub> are best described by the Korsemeyer-Peppas (R<sup>2</sup> = 0.9738 and 0.9802 respectively) whereas E<sub>4</sub> followed Zero order kinetic model (R<sup>2</sup> = 0.9844). However, the Carbopol 940 matrix tablet, C<sub>1</sub>-C<sub>2</sub> followed the Korsemeyer-Peppas model (R<sup>2</sup> = 0.9795 and 0.9732 respectively). Also while C<sub>3</sub> best fits Higuchi kinetics (R<sup>2</sup> = 0.9853), the C4 is best explained using the zero order (0.9711). Conclusion: Although tablets of larger sized granules irrespective of the polymer used were best described by zero order (E<sub>4</sub> and C<sub>4</sub>), the smaller sizes (E<sub>2</sub> and C<sub>2</sub>) followed Korsemeyer-Peppas model, the polymer used or granule size had no statistically significant effect on the percentage drug release of ibuprofen from tablet matrix.
%K Release Kinetics
%K Granule Size
%K Ibuprofen
%K Sustained-Release Tablet
%K Polymer-Drug Matrix
%U http://www.oalib.com/paper/6763435