%0 Journal Article
%T Non-Carcinogenic Genotoxic Drugs Could Be Used to Prevent and Treat COVID-19
%A Gao-De Li
%J Open Access Library Journal
%V 7
%N 7
%P 1-6
%@ 2333-9721
%D 2020
%I Open Access Library
%R 10.4236/oalib.1106536
%X Three-dimensional (3D) genome structure plays an important role in the regulation of gene expression. Alteration of 3D genome structure can change cell¡¯s gene expression pattern that causes cellular function change and thus could be used as a novel therapy for treating many diseases including COVID-19. Genotoxic drug is the only drug that could be used to alter 3D genome structure. Since at present no purpose-made non-carcinogenic genotoxic drugs for altering genome structure are available and fighting COVID-19 must be done without delay, it is possible to repurpose some old drugs as non-carcinogenic genotoxic drugs that can be used to reduce target cell¡¯s susceptibility to SARS- CoV-2 which causes COVID-19 and to modulate immune cell¡¯s response to SARS-CoV-2 infection through altering 3D genome structures in target cells and immune cells.
%K Three-Dimensional Genome Structure
%K Non-Carcinogenic Genotoxic Drugs
%K Chloroquine
%K Hydroxychloroquine
%K SARS-CoV-2
%K Coronavirus Disease 2019 (COVID-19)
%U http://www.oalib.com/paper/5435973