%0 Journal Article
%T Mechanochemical Synthesis of Rosuvastatin Intermediates by Liquid-Assisted Wittig Reaction
%A Jianbo Yan
%A Chengjun Jiang
%J Open Access Library Journal
%V 7
%N 6
%P 1-7
%@ 2333-9721
%D 2020
%I Open Access Library
%R 10.4236/oalib.1106421
%X Liquid-assisted Wittig reaction is used to synthesis of Rosuvastatin intermediates (1,3-Dioxane-4-acetic acid, (4R,6S)-6-[(1E)-2-[4-(4-fluorophenyl)-6- (1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,1-dimethylethyl ester). Evaluate the reaction using common green chemistry metrics: environmental factor (E-factor), and systematic investigation of the reaction has been made in order to study the various factors affecting the reaction. The E-factor of Liquid-assisted Wittig reaction is about a quarter of the traditional method. Under optimal conditions, the conversion rate can reach 99.2 and the E:Z ratio can reach 76:24.
%K Wittig Reaction
%K Synthesis
%K Rosuvastatin Intermediates
%U http://www.oalib.com/paper/5435333