%0 Journal Article %T Approach to Primary Immunodeficiencies for the Non-Immunologist Physicians %A Garc¨ªa-L¨®pez Carlos Alberto %A Alc¨¢zar-Casar¨ªn Emmanuel %A Ynga-Durand Mario Alberto %A Alonso-Bello C¨¦sar Daniel %A Lozano-Patino Fernando %A Vargas-Camano Mar¨ªa Eugenia %A Espinosa-Padilla Sara Elva %A Gonz¨¢lez-Serrano Maria Edith %A Castrej¨®n-V¨¢zquez Mar¨ªa Isabel %J Open Access Library Journal %V 6 %N 5 %P 1-15 %@ 2333-9721 %D 2019 %I Open Access Library %R 10.4236/oalib.1105419 %X
Introduction: Primary immunodeficiencies are a spectrum of diseases that encompasses alteration of the innate and adaptive immune response. Isolated lymphocytopenia may be a manifestation of primary immunodeficiency, which is rarely considered as a diagnostic option by non-immunological physicians. Objectives: To conduct a brief review of the primary immunodeficiencies that are most frequently associated with lymphocytopenia in order to provide a resource that will help non-immunological clinicians to recognize and appropriately refer to these cases. Materials and Methods: Review of the literature with scientific articles indexed in English and Spanish. We consulted Pubmed database with the keywords: primary immunodeficiencies and severe combined immu-nodeficiencies. The limit of time was 5 years and only review papers. Re-sults: The search in the database results in 68 papers and we analyzed 35 articles because the objective of the review was Severe Combined Immu-nodeficiencies. Discussion: Persistent lymphopenia (usually <2500 xmm3) detected in blood cell cytometry that accompanies severe, recurrent infec-tions, autoimmune manifestations, atopy and cancer may suggest severe combined immunodeficiency. Causes of secondary immunodeficiency such as HIV should be ruled out. Conclusions: Persistent lymphopenia can be associated with severe combined immunodeficiency. The study should be extended in these cases by a specialist or refer the patient to a referral center for a complete evaluation.
%K Primary Immunodeficiencies %K Immunodeficiency %K Approach %K Lymphopenia %U http://www.oalib.com/paper/5361615