%0 Journal Article %T Efficacy of a Combination of Tanacetum parthenium, 5-Hydroxy Tryptophan and Magnesium (Aurastop) in Episodic Migraine Prevention: A Multicentric Observational Study %A Federico Mainardi %A Paola Merlo %A Ferdinando Maggioni %A Giorgio Zanchin %A Giorgio Dalla Volta %J Open Access Library Journal %V 5 %N 8 %P 1-9 %@ 2333-9721 %D 2018 %I Open Access Library %R 10.4236/oalib.1104765 %X
Objective: To verify the efficacy and safety of the new combination of Tanacetum parthenium 150 mg, 5-hydrossitriptophan (5-HTTP) 20 mg and magnesium 185 mg (Aurastop) in the prophylactic treatment of episodic migraine without aura (MO). Methods: Eighty patients suffering from MO for at least 6 months with a monthly frequency of 3 to 8 attacks and 4 to12 headache days, were enrolled in this open study and treated with Aurastop twice daily per os for 3 months. The reduction of headache days per month was assessed as the primary end-point, while the secondary end-points were: 1) reduction of the number of MO attacks; 2) reduction of intensity of the pain; 3) reduction of acute treatment drug intake; 4) subjective change of pain intensity. Results: All the parameters significantly improved at the end of the observational period of treatment with Aurastop. In more detail: a significant reduction of the number of headache days (from 9.1 ¡À 2.0 before treatment to 3.2 ¡À 1.8 post treatment, p < 0.001); number of attacks per month (from 6.0 ¡À 1.2 to 2.4 ¡À 1.1, p < 0.001); pain intensity (in a visual analogical scale [VAS]: from 7 ¡À 1.0 to 3.2 ¡À 0.7, p < 0.001); number of drug doses for acute treatment (triptans, simple analgesics or in combination) assumed by each subject per month (from 9.5 ¡À 1.8 to 2.2 ¡À 1.1, p < 0.001). No serious adverse events were observed. Conclusion: Albeit obtained with the limitation of open-trials, our findings suggest that AURASTOP is a promising approach for migraine prevention; further investigations are required to confirm the safety and efficacy of this treatment.
%K Migraine without Aura %K Kynurenine Pathway %K Tanacetum parthenium %U http://www.oalib.com/paper/5298295