%0 Journal Article
%T Papillary Carcinoma Arising in Thyroglossal Duct Cyst: A Retrospective Analysis (Cancer of the Thyroid or Primary Cancer of the Thyroglossal Cyst)
%A Paolo Gamba
%A Umberto Pignatelli
%A Giampiero DĄŻAddazio
%A Gabriella Licursi
%A Luca Gentile
%A Ugo Moz
%J Open Access Library Journal
%V 5
%N 1
%P 1-12
%@ 2333-9721
%D 2018
%I Open Access Library
%R 10.4236/oalib.1104259
%X
Thyroglossal duct cysts
are one of the most common congenital abnormalities of the cervical region.
Complications of these swellings are rare, and among these, appearance of a
carcinoma has also been noted. Thyroglossal duct cyst carcinoma (TGDC) is a
rare entity and its management is controversial. The incidence of thyroid
papillary carcinoma in thyroglossal duct cyst is less than 1%, in most cases, the diagnosis is made postoperatively. We report
the case of an adult female patient with a papillary carcinoma arising in a
thyroglossal duct cyst. Our aim is defining a clinical protocol to diagnose the
thyreoglossal duct carcinoma through clinical features, radiological
investigations, cytological and histopathological examinations and, through
this diagnostic protocol, to choose the best surgical approach. The literature contains 300 cases of this pathology; papillary histotype
constitutes about 80%, then squamocellular carcinoma, mixed folliculo-papillary
carcinoma and adenocarcinoma follow. The literature suggests two different hypotheses:
neoplasia originating from ectopic thyroid tissue and plurifocal theory. The
adopted diagnostic investigations are: ultrasonography, Fine Needle Aspiration
Biopsy (FNAB), Magnetic Resonance Imaging (MRI). Our patient was treated using
a modified SistrunkĄŻs procedure operation,
in which thyroidectomy proved crucial for the correct diagnosis and continuation
of appropriate treatment. Our case confirms the difficulty in distinguishing a
primitive thyroglossal duct carcinoma from a synchronous metastatic papillary
carcinoma of the thyroid. This dilemma often remains unresolved. The two different surgical approaches reported in
the literature, one more conservative and the other more aggressive, apparently
alternatives are instead complementary
and adequate when strict diagnostic criteria and adequate follow-up, are
observed. The first year follow-up includes the thyroglobulin level determination
and a neck ecografic scan every 3 months. The patient has been following for
two years without any metastasis.
%K Thyroglossal Duct
%K Thyroglossal Cyst
%K Thyroid Carcinoma
%K Papillary Carcinoma
%K Thyroglossal Duct Cyst Carcinoma
%K Sistrunk Procedure
%U http://www.oalib.com/paper/5292448