%0 Journal Article
%T Ionic Liquid Based Ultrasonic-Assisted Extraction of Oleanolic Acid from Grape Seeds
%A Xifeng Zhang
%A Xue Li
%A Qian He
%A Bin Zhang
%A Xue Zheng
%J Open Access Library Journal
%V 4
%N 12
%P 1-16
%@ 2333-9721
%D 2017
%I Open Access Library
%R 10.4236/oalib.1104148
%X <div style="text-align:justify;">
	<span style="line-height:1.5;">Ionic liquid based
ultrasonic-assisted extraction (ILUAE) was successfully applied to extract
Oleanolic acid (OA)
from grape seeds. Different kinds of 1-alkyl-3-methylimidazolium ionic liquids
with different kinds of cations and anions were studied and
1-butyl-3-methylimidazolium chloride ([C</span><sub>4</sub><span style="line-height:1.5;">mim]Cl) solution was
selected as extractants. The optimal conditions of ILUAE were determined by
single factor experiments and Box-Be</span><span style="line-height:1.5;">hnken design as follows: [C</span><sub>4</sub><span style="line-height:1.5;">mim]Cl
concentration of 0.7 mol/L,
extraction time of 4 h,
liquid-solid ratio of 15:1 mL/g,
ultrasonic power of 195 W, the
ultrasonication time of 13 min,
and extraction temperature of 48ˇćˇ¤min. The extraction yield of
OA was 13.4 mg/g, which is well in close agreement
with the value predicted by the model. Compared with the regular
ultrasonic-assisted extraction (UAE), the proposed approach exhibited 1.64
times higher efficiency, which indicated that ILUAE has a broad prospect for
sample preparation of the bioactive compounds.</span> 
</div>
%K Ionic-Liquid Based Ultrasound-Assisted (ILUAE)
%K Oleanolic Acid
%K Grape Seeds
%U http://www.oalib.com/paper/5291503