%0 Journal Article
%T Therapeutic Specificities and Prognosis of Advanced Stage and Metastatic Bladder Cancers in a Tunisian University Hospital
%A Zaied Sonia
%A Khechine Wiem
%A Bourigua Rim
%A Abbess Ibtissem
%A Ktari Kamel
%A Ben Ali Yosri
%A Daldoul Amira
%J Open Access Library Journal
%V 4
%N 10
%P 1-14
%@ 2333-9721
%D 2017
%I Open Access Library
%R 10.4236/oalib.1103894
%X <div style="text-align:justify;">
	<span style="line-height:1.5;">In Tunisia, bladder cancer represents the first urological cancer before
even prostate cancer. However, its diagnosis is often delayed to the stage of
invasive tumor. Systemic chemotherapy represents an option for inoperable
and/or metastatic forms. Our study¡¯s aims were to report our center¡¯s therapeutic
results for locally advanced and metastatic forms of bladder cancer and to
analyze its prognosis factors. In our 40 patients with bladder cancer advanced
stages (locally advanced and metastatic), transitional cell carcinoma was the
most common histological type (82.5%); mean age at diagnosis was 63.3 ¡À 10.5
years with a sex ratio equal to 12.3; radical cystectomy and radiation therapy
were performed separately both in 35% of cases and chemotherapy in 60%;
cisplatin associated with gemcitabine was the most used regimen and </span><span style="line-height:1.5;">navelbine monotherapy was used as
second-line chemotherapy; median overall survival was 14.4 months, and its influencing
factors according to our results were: ECOG score, T and M tumor stages,
primary tumor surgery and adjuvant chemotherapy.</span>
</div>
%K Bladder Neoplasms
%K Epidemiology
%K Treatment
%K Prognosis
%U http://www.oalib.com/paper/5289572