%0 Journal Article
%T Seroprevalence Virus in Human Immunodeficiency Sickle Cell Anemia Duffy-46C/C in Democratic Republic of Congo¡ªCase of the City of Kinshasa and Lubumbashi
%A P. Lungu Anzwal
%A A. Kambote Kalumba
%A J. Kasali Mwamba
%A Saragosti S. Sentob
%A H. Situakibanza Nani Tuma
%A Ekwalanga M. Balaka
%J Open Access Library Journal
%V 4
%N 7
%P 1-7
%@ 2333-9721
%D 2017
%I Open Access Library
%R 10.4236/oalib.1103697
%X
Homozygous sickle cell disease undergoes multiple blood
transfusions during their life because of chronic hemolytic anemia associated
with their condition and the risk of infection is most convincing, for example
vis-¨¤-vis certain viruses such as HIV, the virus hepatitis. This study
aims to determine the HIV seroprevalence among sickle cell anemia Duffy-46C/C. This
is a cross-sectional descriptive study to determine HIV seroprevalence in Duffy-46C/C
sickle-cell anemia, conducted at the Yolo Sud SS Joint Medical Center in St.
Crispin in Kinshasa and Jason Sendwe Hospital in Lubumbashi, from 2015 to 2016. HIV seroprevalence of 505 subjects
homozygous sickle cell Duffy-46C/C was established by
Immuno-chromatography tests determined HIV1/2 test Uni-Gold to determine the
anti-HIV antibodies. CD4
rate was also determined and plasma viral load. We collected 505 samples of
blood from sickle cell anemia aged from 1 year to 65 years (mean age 15.6
years) with 235 subjects male and 270 female subjects. A positive serology was
found in 6 cases (1.19%), including 5 female subjects of which 4 cases had
received 1-5 transfusions and 2 cases
were vaso-occlusive crisis (VOC). Viral load was determined, and 4 individuals were
detectable and 2 were undetectable. Their CD4 levels were raised to more than 500 c/¦̀L, ranging between 543 to 893 c/¦̀l. The blood transfusion remains a risk in the
transmission of HIV/AIDS among people polytransfusees, due probably to the
window door. We will have to strengthen blood safety by equipping laboratories
and blood banks with reliable early tests that detect viral RNA of HIV.
%K HIV
%K Sickle Cell Anemia Duffy-46C/C
%K Blood Transfusion
%U http://www.oalib.com/paper/5287134