%0 Journal Article
%T Cell-Cycle-Associated Amplified Genomic-DNA Fragments (CAGFs) Might Be Involved in Chloroquine Action and Resistance in <i>Plasmodium falciparum</i>
%A Gao-De Li
%J Open Access Library Journal
%V 4
%N 3
%P 1-11
%@ 2333-9721
%D 2017
%I Open Access Library
%R 10.4236/oalib.1103451
%X <div style="text-align:justify;">
	<span style="line-height:1.5;">As
a cheap and safe antimalarial agent, chloroquine (CQ) has been used in the battle against malaria for more than half century.
However, the mechanism of CQ action and resistance in </span><i style="line-height:1.5;">Plasmodium falciparum</i><span style="line-height:1.5;"> remains elusive. Based on further analysis of our published experimental results, we propose that
the mechanism of CQ action and resistance
might be closely linked with cell-cycle-associated amplified genomic-DNA fragments
(CAGFs, singular form = CAGF) as CQ induces CAGF
production in </span><i style="line-height:1.5;">P. falciparum</i><span style="line-height:1.5;">, which
could affect multiple biological processes of the parasite, and thus might
contribute to parasite death an</span><span style="line-height:1.5;">d CQ resistance. Recently, we found that CQ
induced one of CAGFs, UB1-CAGF, might downregulate a probable</span><i style="line-height:1.5;"> P. falciparum </i><span style="line-height:1.5;">cystine transporter
(Pfct) gene expression, which could be used to understand the mechanism of CQ
action and resistance in </span><i style="line-height:1.5;">P. falciparum</i><span style="line-height:1.5;">.</span>
</div>
%K <i>Plasmodium falciparum</i>
%K Chloroquine Resistance
%K Cell-Cycle-Associated Amplified Genomic-DNA Fragment (CAGF)
%K <i>Plasmodium falciparum</i> Cystine Transporter (Pfct)
%K Glutathione (GSH)
%K Reactive Oxygen Species (ROS)
%K Pfcrmp
%U http://www.oalib.com/paper/5282873