%0 Journal Article
%T Color Doppler Ultrasonography and Diffusion Weighted Magnetic Resonance Enterography in Pediatric Ibd: Comparison with Histology in the Evaluation of Disease Severity
%A Salinaro Emanuela
%A Mancini Maria Elisabetta
%A De Venuto Domenica
%A Gallone Maria Filomena
%A Russo Silvana
%A Monteduro Mariantonietta
%A Angelelli Giuseppe
%J Open Access Library Journal
%V 3
%N 2
%P 1-12
%@ 2333-9721
%D 2016
%I Open Access Library
%R 10.4236/oalib.1102406
%X Objectives: The purpose of this study was to retrospectively compare color
Doppler Ultrasonography (CD-US) and diffusion weighted Magnetic Resonance Enterography
(DWI-MRE) in the eva- luation of disease severity of pediatric inflammatory bowel
diseases (IBD). Materials and methods: During the period between February 2010 and
November 2012, 36 patients affected by IBD, aged between 7.8 and 18.5 years (mean
11.9 years) underwent, in the same week, CD-US, DWI-MRE [completed by apparent diffusion
coefficient (ADC) calculation] and ileocolonoscopy with intestinal biopsies. Overall,
53 bowel segments (27 ileal, 26 colonic) were examined. At CD-US evaluation, a wall
thickness > 3 mm in the small bowel and >2 mm in the large bowel, associated
with an increased intramural vascularity, were considered abnormal. ADC values were
significant when lower than 2 กม 10<sup>ฉ3</sup> mm<sup>2</sup>/sec. Histopathological
grading of inflammation distinguished between active (mild, moderate and severe)
and inactive disease. For each segment, CD-US findings and ADC values were compared
with histology. Results: CD-US correctly graded 46/53 cases (86.8%) as compared
with histology. Statistical analysis demonstrated a negative correlation between
ADC and histology, with the results corresponding in 43/53 cases (81.1%). Conclusions:
Our study shows that both CD-US and DWI-MRE are non-invasive, useful diagnostic
tools for the grading of IBD activity in children.
%K Pediatric IBD
%K Crohn Disease
%K Ulcerative Colitis
%K Bowel Ultrasonography
%K Magnetic Resonance En-terography
%K Disease Activity
%K Diffusion Weighted Imaging
%K Radiation Exposure
%U http://www.oalib.com/paper/4918271